Western · Mitophagy activator
Urolithin A
尿石素 A
76Confidence
Human RCT evidence
- RCTs
- 25
- Meta
- 5
- Trials
- 31
Key active: Urolithin A (gut-microbial metabolite)
Human RCTs (muscle, mitochondria); clear mechanism
Urolithin A induces mitophagy (recycling of damaged mitochondria); randomized human trials report improved muscle endurance and mitochondrial gene expression in older adults.
Full Urolithin A evidence →Western · Mitochondrial cofactor
Coenzyme Q10
辅酶 Q10
76Confidence
Extensive human-trial evidence
- RCTs
- 523
- Meta
- 198
- Trials
- 251
Key active: Coenzyme Q10 (ubiquinone / ubiquinol)
Human RCTs (cardiovascular, statin myopathy); mitochondrial rationale
CoQ10 is essential to the mitochondrial respiratory chain and acts as a lipid-phase antioxidant; the KiSel-10 trial linked CoQ10 plus selenium to reduced cardiovascular mortality in older adults.
Full Coenzyme Q10 evidence →