Origin & tradition
Not traditional: creatine is an endogenous compound popularized first in sports science, now studied for healthy aging.
Western tradition · Muscle & brain energy
Creatine 肌酸
One of the most evidence-backed supplements anywhere — for muscle, and increasingly for the aging brain.
Why longevity buyers care
Key active: Creatine monohydrate.
Creatine buffers cellular ATP; combined with resistance training it counters sarcopenia in older adults, and trials are exploring cognitive and mood benefits under metabolic stress.
Evidence summary
What the research actually says
84Evidence confidence
Extensive human-trial evidence188 randomized controlled trials · 21 meta-analyses / systematic reviews
Strong human RCTs (muscle/sarcopenia); growing cognitive data
Creatine buffers cellular ATP; combined with resistance training it counters sarcopenia in older adults, and trials are exploring cognitive and mood benefits under metabolic stress.
339registered clinical trials reference this intervention
3selected from 4+ PubMed papers (longevity / aging angle)
Key active: Creatine monohydrate.
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-06. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
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