Origin & tradition
NMN is not a traditional remedy but a modern molecule at the center of the NAD+ longevity field studied at Harvard and Washington University. NAD+, the coenzyme it feeds, declines with age.
Western tradition · NAD+ precursor · Longevity supplement
NMN (Nicotinamide Mononucleotide) β-烟酰胺单核苷酸
The headline NAD+ booster of the longevity world — human trials show it raises blood NAD+ and may support physical function.
Why longevity buyers care
Key active: Nicotinamide mononucleotide (NAD+ precursor).
NMN is a direct precursor to NAD+, the coenzyme that fuels mitochondrial energy and sirtuin activity and declines with age. A 2022 randomized, placebo-controlled trial in healthy middle-aged adults found dose-dependent increases in blood NAD+ and improved six-minute walking distance.
Evidence summary
What the research actually says
79Evidence confidence
Human RCT evidence17 randomized controlled trials · 10 meta-analyses / systematic reviews
Human RCTs on NAD+ levels & physical function; long-term longevity outcomes still open
NMN is a direct precursor to NAD+, the coenzyme that fuels mitochondrial energy and sirtuin activity and declines with age. A 2022 randomized, placebo-controlled trial in healthy middle-aged adults found dose-dependent increases in blood NAD+ and improved six-minute walking distance.
31registered clinical trials reference this intervention
2selected from 30+ PubMed papers (longevity / aging angle)
Key active: Nicotinamide mononucleotide (NAD+ precursor).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-06. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Compare the evidence
How NMN (Nicotinamide Mononucleotide) stacks up
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