Origin & tradition
Resveratrol bridges East and West: abundant in red grapes and red wine, it is also the key active in Hu Zhang (虎杖, Japanese knotweed), a herb used in traditional Chinese medicine.
Both tradition · Polyphenol · sirtuin activator
Resveratrol 白藜芦醇
The grape-and-knotweed polyphenol that launched the sirtuin era of longevity research.
Why longevity buyers care
Key active: Resveratrol (stilbene polyphenol).
Resveratrol is studied as a SIRT1 activator and calorie-restriction mimetic acting on AMPK, NRF2 and telomere/senescence pathways. Reviews report improved healthspan and lifespan across model organisms; human results are more mixed and formulation-dependent.
Evidence summary
What the research actually says
74Evidence confidence
Extensive human-trial evidence270 randomized controlled trials · 262 meta-analyses / systematic reviews
Large model-organism + human literature; sirtuin / CR-mimetic mechanism; human outcomes mixed
Resveratrol is studied as a SIRT1 activator and calorie-restriction mimetic acting on AMPK, NRF2 and telomere/senescence pathways. Reviews report improved healthspan and lifespan across model organisms; human results are more mixed and formulation-dependent.
230registered clinical trials reference this intervention
2selected from 12+ PubMed papers (longevity / aging angle)
Key active: Resveratrol (stilbene polyphenol).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-06. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Compare the evidence
How Resveratrol stacks up
Verified suppliers
No verified Resveratrol suppliers listed yet
Tell us what you need and we will source verified suppliers for you.