Origin & tradition
Wu Wei Zi (五味子) is a classic Chinese adaptogen used to support the liver, calm the spirit, and build endurance.
Eastern tradition · Tonic Herbs
Schisandra 五味子
The “five-flavor berry,” an adaptogen studied for liver protection, stress resilience, and cellular defense.
Why longevity buyers care
Key active: Schisandrins / lignans (botanical extract).
Schisandra lignans (schisandrin B) are studied for Nrf2-mediated antioxidant defense and hepatoprotection; aging-specific human evidence is limited.
Evidence summary
What the research actually says
69Evidence confidence
Human RCT evidence16 randomized controlled trials · 10 meta-analyses / systematic reviews
Preclinical hepatoprotection + small human stress/liver trials
Schisandra lignans (schisandrin B) are studied for Nrf2-mediated antioxidant defense and hepatoprotection; aging-specific human evidence is limited.
24registered clinical trials reference this intervention
3selected from 20+ PubMed papers (longevity / aging angle)
Key active: Schisandrins / lignans (botanical extract) — a multi-compound botanical extract, so activity is not reducible to a single molecule.
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-06. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
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