Origin & tradition
Spermidine occurs naturally in wheat germ, natto, aged cheese and other fermented foods; its longevity link emerged from modern autophagy research rather than any single tradition.
Western tradition · Polyamine · autophagy inducer
Spermidine 亚精胺
A fasting-mimicking polyamine that triggers autophagy and extends lifespan across species.
Why longevity buyers care
Key active: Spermidine (natural polyamine).
Spermidine induces autophagy via hypusination of eIF5A and histone deacetylation, mimicking fasting. Landmark studies in yeast, flies, worms, mice and human cells link it to lifespan extension, cardioprotection and reduced age-related disease.
Evidence summary
What the research actually says
80Evidence confidence
Human RCT evidence43 randomized controlled trials · 8 meta-analyses / systematic reviews
Strong cross-species lifespan evidence; human trials emerging (autophagy, cognition)
Spermidine induces autophagy via hypusination of eIF5A and histone deacetylation, mimicking fasting. Landmark studies in yeast, flies, worms, mice and human cells link it to lifespan extension, cardioprotection and reduced age-related disease.
21registered clinical trials reference this intervention
3selected from 73+ PubMed papers (longevity / aging angle)
Key active: Spermidine (C7H19N3) · ChEMBL CHEMBL19612 · max clinical phase 3 · natural product
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed, compound data from EMBL-EBI ChEMBL. Counts auto-refresh weekly; last checked 2026-06-06. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Compare the evidence
How Spermidine stacks up
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