Origin & tradition
Not traditional: vitamin D's role emerged from bone and endocrine science; sunlight is its natural source.
Western tradition · Vitamin
Vitamin D3 维生素 D3
A foundational hormone-vitamin where deficiency is common and consequential for aging health.
Why longevity buyers care
Key active: Cholecalciferol (vitamin D3).
Vitamin D regulates calcium, immune function, and gene expression; while megatrials (VITAL) were mixed on hard endpoints, deficiency correction supports bone, falls, and immune resilience in older adults — and recent work links it to telomere/biological-aging markers.
Evidence summary
What the research actually says
79Evidence confidence
Extensive human-trial evidence2,615 randomized controlled trials · 331 meta-analyses / systematic reviews
Large RCTs (mixed on endpoints); deficiency correction matters
Vitamin D regulates calcium, immune function, and gene expression; while megatrials (VITAL) were mixed on hard endpoints, deficiency correction supports bone, falls, and immune resilience in older adults — and recent work links it to telomere/biological-aging markers.
1,637registered clinical trials reference this intervention
1selected from 1+ PubMed papers (longevity / aging angle)
Key active: Cholecalciferol (vitamin D3).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-06. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
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