Origin & tradition
Not traditional: marine omega-3s entered medicine through cardiovascular epidemiology and large randomized trials.
Western tradition · Essential fatty acids
Omega-3 (EPA/DHA) 欧米伽-3 脂肪酸
Among the most-trialed supplements in medicine, with emerging evidence on biological-age slowing.
Why longevity buyers care
Key active: EPA & DHA (marine omega-3 fatty acids).
EPA and DHA modulate inflammation (resolvins), membrane function, and triglycerides; the DO-HEALTH trial reported small reductions in biological-aging markers and infections in older adults.
Evidence summary
What the research actually says
82Evidence confidence
Extensive human-trial evidence4,572 randomized controlled trials · 1,481 meta-analyses / systematic reviews
Very large human RCT base; aging markers emerging (DO-HEALTH)
EPA and DHA modulate inflammation (resolvins), membrane function, and triglycerides; the DO-HEALTH trial reported small reductions in biological-aging markers and infections in older adults.
1,963registered clinical trials reference this intervention
3selected from 9+ PubMed papers (longevity / aging angle)
- Systemic immune inflammation mediates the association of serum omega-3 and omega-6 polyunsaturated fatty acids with biological aging: a national population-based study
- Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation
- The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation
Key active: EPA & DHA (marine omega-3 fatty acids).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-06. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Compare the evidence
How Omega-3 (EPA/DHA) stacks up
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